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MCQ
What is the rate-determining step in the acid-catalyzed esterification of a carboxylic acid?
Chemistry
A Protonation of the carbonyl oxygen
B Nucleophilic attack of the alcohol on the protonated carbonyl
C Deprotonation to form the ester
D Loss of water from the tetrahedral intermediate
Explanation

After proton activation of the carbonyl, the slowest step is the nucleophilic addition of the alcohol to form the tetrahedral intermediate.

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